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Livres
Articles (121)
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The expanding utility of microdosing

Lappin, Graham

Journal:

Clinical Pharmacology in Drug Development

Année:

2015

Langue:

english

Fichier:

PDF, 127 KB

english, 2015

Insights into the Ecology and Evolutionary Success of Crocodilians Revealed through Bite-Force and Tooth-Pressure Experimentation

Erickson, Gregory M., Gignac, Paul M., Steppan, Scott J., Lappin, A. Kristopher, Vliet, Kent A., Brueggen, John D., Inouye, Brian D., Kledzik, David, Webb, Grahame J. W., Claessens, Leon

Journal:

PLoS ONE

Année:

2012

Langue:

english

Fichier:

PDF, 572 KB

english, 2012

Synthesis and accumulation of polygodial by tissue cultures of Polygonum hydropiper

Derek V. Banthorpe, Charles J.W. Brooks, Jacqueline T. Brown, Graham J. Lappin, George S. Morris

Journal:

Phytochemistry

Année:

1989

Langue:

english

Fichier:

PDF, 350 KB

english, 1989

Stereoselectivity in electron transfer reactions involving metal ion complexes

A.Graham Lappin, Rosemary A. Marusak

Journal:

Coordination Chemistry Reviews

Année:

1991

Langue:

english

Fichier:

PDF, 3.87 MB

english, 1991

Reactions between copper(II) and 2-mercaptosuccinic acid in aqueous perchlorate solution

Lappin, A. Graham, McAuley, Alexander

Journal:

Journal of the Chemical Society Dalton Transactions

Année:

1978

Langue:

english

Fichier:

PDF, 476 KB

english, 1978

Microdosing and drug development: past, present and future

Lappin, Graham, Noveck, Robert, Burt, Tal

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2013

Langue:

english

Fichier:

PDF, 380 KB

english, 2013

The (Tetraazaannulene)copper-Catalyzed Reduction of Sulfur(IV) Species. A Pulse-Radiolysis and Theoretical Study of the Associated Reaction Mechanism

Guillermo Ferraudi, Guillermina Estiu, A. Graham Lappin, Manuel Villagran, Juan P. Muena, Juan Costamagna, Jose Zagal

Journal:

Helvetica Chimica Acta

Année:

2009

Langue:

english

Fichier:

PDF, 426 KB

english, 2009

The oxidation of [Co(edta)]2− by [Co(phen)3]3+

Robert M.L. Warten, Lars Öhrström, Gregory J. Opiteck, Maoyu Shang, A.Graham Lappin

Journal:

Inorganica Chimica Acta

Année:

1994

Langue:

english

Fichier:

PDF, 874 KB

english, 1994

Slow electron exchange at tetrahedral copper

A.Graham Lappin, Robert D. Peacock

Journal:

Inorganica Chimica Acta

Année:

1980

Langue:

english

Fichier:

PDF, 214 KB

english, 1980

Shape selectivity in outer-sphere electron transfer reactions

Tsuyoshi Mitani, Nobuyuki Honma, Akira Tatehata, A.Graham Lappin

Journal:

Inorganica Chimica Acta

Année:

2002

Langue:

english

Fichier:

PDF, 159 KB

english, 2002

Effects of electronic structure on chiral induction in outer-sphere electron transfer reactions of complexes with the C3 symmetric ligand, 1,4,7-triazacyclononane-1,4,7-tris[2′(R)-2′-propionate](-3)

Donovan A Dixon, Maoyu Shang, A.Graham Lappin

Journal:

Inorganica Chimica Acta

Année:

1999

Langue:

english

Fichier:

PDF, 174 KB

english, 1999

Biotransformation of monoterpenoids by suspension cultures of Lavandula angustifolia

Graham J. Lappin, John D. Stride, John Tampion

Journal:

Phytochemistry

Année:

1987

Langue:

english

Fichier:

PDF, 325 KB

english, 1987

Reduction of the copper(II) cation in acetonitrile by trimethyl phosphite. Evidence for an intermediate copper(II) complex

Gerard M. Anderson, James H. Cameron, A.Graham Lappin, John M. Winfield, Alexander McAuley

Journal:

Polyhedron

Année:

1982

Langue:

english

Fichier:

PDF, 214 KB

english, 1982

Structure and magnetic properties of [Cr(en)2(ox)][Cr(en)(ox)2]·2H2O,Δ-[Cr(en)3]Δ-[Cr(ox)3] and Δ-[Co(en)3]Δ-[Cr(ox)3]

Xaio Hua, Krister Larsson, Teresa J. Neal, Graeme R.A. Wyllie, Maoyu Shang, A. Graham Lappin

Journal:

Inorganic Chemistry Communications

Année:

2001

Langue:

english

Fichier:

PDF, 118 KB

english, 2001

A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of11C- and14C-labelled verapamil in healthy volunteers

Claudia C Wagner, Marie Simpson, Graham Lappin, Rudolf Karch, Aiman Abrahim, Thomas Feurstein, Martin Bauer, Markus Zeitlinger, Kurt Kletter, Markus Müller, Oliver Langer

Journal:

BMC Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 107 KB

english, 2008

Current perspectives of14C-isotope measurement in biomedical accelerator mass spectrometry

Graham Lappin, R.Colin Garner

Journal:

Analytical and Bioanalytical Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 195 KB

english, 2004

Driving force effects in proton coupled electron transfer

Mauro C.M. Laranjeira, Rosemary A. Marusak, A.Graham Lappin

Journal:

Inorganica Chimica Acta

Année:

2000

Langue:

english

Fichier:

PDF, 98 KB

english, 2000

Commentary : The phase 0 microdosing concept

R. Colin Garner, Graham Lappin

Journal:

British Journal of Clinical Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 115 KB

english, 2006

A pharmacokinetic evaluation of five H1 antagonists after an oral and intravenous microdose to human subjects

Ajay Madan, Zhihong O'Brien, Jianyun Wen, Chris O'Brien, Robert H. Farber, Graham Beaton, Paul Crowe, Berend Oosterhuis, R. Colin Garner, Graham Lappin, Haig P. Bozigian

Journal:

British Journal of Clinical Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 829 KB

english, 2009

Big physics, small doses: the use of AMS and PET in human microdosing of development drugs

Lappin, Graham, Garner, R. Colin

Journal:

Nature Reviews Drug Discovery

Année:

2003

Langue:

english

Fichier:

PDF, 519 KB

english, 2003

Erythropoietin Receptor Expression in Non-Small Cell Lung Carcinoma: A Question of Antibody Specificity

W. Mark Brown, Perry Maxwell, Alastair N.J. Graham, Anita Yakkundi, Elaine A. Dunlop, Zhanzhong Shi, Patrick G. Johnston, Terence R.J. Lappin

Journal:

STEM CELLS

Année:

2007

Langue:

english

Fichier:

PDF, 437 KB

english, 2007

Pharmacokinetics of fexofenadine: Evaluation of a microdose and assessment of absolute oral bioavailability

Graham Lappin, Yoko Shishikura, Roeline Jochemsen, Richard John Weaver, Charlotte Gesson, Brian Houston, Berend Oosterhuis, Ole J. Bjerrum, Malcolm Rowland, Colin Garner

Journal:

European Journal of Pharmaceutical Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 350 KB

english, 2010

Comparative pharmacokinetics between a microdose and therapeutic dose for clarithromycin, sumatriptan, propafenone, paracetamol (acetaminophen), and phenobarbital in human volunteers

Graham Lappin, Yoko Shishikura, Roeline Jochemsen, Richard John Weaver, Charlotte Gesson, J. Brian Houston, Berend Oosterhuis, Ole J. Bjerrum, Grzegorz Grynkiewicz, Jane Alder, Malcolm Rowland, Colin

Journal:

European Journal of Pharmaceutical Sciences

Année:

2011

Langue:

english

Fichier:

PDF, 608 KB

english, 2011

Synthesis, spectral, electrochemical and flash photolysis studies of Fe(II), Ni(II) tetrapyridylporphyrins coordinated at the periphery with chromium(III) phenanthroline complexes

Camilo García, Guillermo Ferraudi, A. Graham Lappin, Mauricio Isaacs

Journal:

Inorganica Chimica Acta

Année:

2012

Langue:

english

Fichier:

PDF, 889 KB

english, 2012

Water-soluble ferric porphyrinates: solution and solid-state species.

Ivanca, Marie A., Lappin, A. Graham., Scheidt, W. Robert.

Journal:

Inorganic Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 1.01 MB

english, 1991

Oxygenation of Cobalt Porphyrinates: Coordination or Oxidation?

Li, Jianfeng, Noll, Bruce C., Oliver, Allen G., Ferraudi, Guillermo, Lappin, A. Graham, Scheidt, W. Robert

Journal:

Inorganic Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 2.29 MB

english, 2010

Pre-operative plasma erythropoietin concentration and survival following surgery for non-small cell lung cancer

Paul, I., Lappin, T.R.J., Maxwell, P., Graham, A.N.J.

Journal:

Lung Cancer

Année:

2006

Langue:

english

Fichier:

PDF, 247 KB

english, 2006

A Combined Accelerator Mass Spectrometry-Positron Emission Tomography Human Microdose Study with14C- and11C-Labelled Verapamil

Claudia C. Wagner, Marie Simpson, Markus Zeitlinger, Martin Bauer, Rudolf Karch, Aiman Abrahim, Thomas Feurstein, Matthias Schütz, Kurt Kletter, Markus Müller, Dr Graham Lappin, Oliver Langer

Journal:

Clinical Pharmacokinetics

Année:

2011

Langue:

english

Fichier:

PDF, 195 KB

english, 2011

Predicting Drug Candidate Victims of Drug-Drug Interactions, using Microdosing

Mrs Marie Croft, Brendan Keely, Ian Morris, Lan Tann, Graham Lappin

Journal:

Clinical Pharmacokinetics

Année:

2012

Langue:

english

Fichier:

PDF, 191 KB

english, 2012

Convenient Synthesis and Characterization of the Chiral Complexes cis - and trans -[Ru(( SS )-Pr i pybox)(py) 2 Cl]PF 6 and [Ru(( SS )-Pr i pybox)(bpy)Cl]PF 6

Hua, Xiao, Shang, Maoyu, Lappin, A. Graham

Journal:

Inorganic Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 204 KB

english, 1997

[Advances in Inorganic Chemistry] Volume 32 || The Redox Chemistry of Nickel

Lappin, A. Graham

Année:

1988

Langue:

english

Fichier:

PDF, 2.45 MB

english, 1988

Meeting the MIST regulations: human metabolism in Phase I using AMS and a tiered bioanalytical approach

Lappin, Graham, Seymour, Mark, Gross, Gerhard, Jørgensen, Martin, Kall, Morten, Kværnø, Lisbet

Journal:

Bioanalysis

Année:

2012

Langue:

english

Fichier:

PDF, 688 KB

english, 2012

A single- and double-flash flash photolysis study of the sequential biphotonic photoprocesses of Cu(i) phenanthrolines. Comparison of the helicate complex, [Cu2(1,3-bis(9-methyl-1,10-phenanthrolin-2-yl)propane)2]2+, and [Cu(2,9-dimethyl-1,10-phenanthroline)2]+ photoprocesses

Lemus, L., Ferraudi, G., Lappin, A. Graham

Journal:

Dalton Transactions

Année:

2013

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2013

Electron-transfer reactions of copper(I) and copper(III) complexes

Lappin, A. Graham, Youngblood, Michael P., Margerum, Dale W.

Journal:

Inorganic Chemistry

Année:

1980

Langue:

english

Fichier:

PDF, 927 KB

english, 1980

Electron-transfer reactions of optically active tris(phenanthroline)cobalt(3+/2+) and derivatives

Warren, Robert M. L., Lappin, A. Graham, Mehta, Brahm Dev, Neumann, H. M.

Journal:

Inorganic Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 677 KB

english, 1990

The influence of oral bacteria on tissue levels of Toll-like receptor and cytokine mRNAs in feline chronic gingivostomatitis and oral health

Dolieslager, Sanne Maria Johanna, Lappin, David Francis, Bennett, David, Graham, Libby, Johnston, Norman, Riggio, Marcello Pasquale

Journal:

Veterinary Immunology and Immunopathology

Année:

2013

Langue:

english

Fichier:

PDF, 528 KB

english, 2013

Transient chiral induction in the reactions of optically active tris(oxalato)cobaltate(3-) with tris(phenanthroline)cobalt(2+) and derivatives

Warren, Robert M. L., Lappin, A. Graham, Tatehata, Akira

Journal:

Inorganic Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 1.82 MB

english, 1992

Disproportionation of nickel(III) bis(oxime imine) complexes

Lappin, A. Graham, Martone, Daniel P., Osvath, Peter

Journal:

Inorganic Chemistry

Année:

1985

Langue:

english

Fichier:

PDF, 595 KB

english, 1985

Resolution and characterization of helicate dimer and trimer complexes of 1,3-bis(9-methyl-1,10-phenanthrolin-2-yl)propane with copper(i)

Lemus, Luis, Guerrero, Juan, Costamagna, Juan, Lorca, Romina, Jara, Danilo H., Ferraudi, Guillermo, Oliver, Allen, Lappin, A. Graham

Journal:

Dalton Transactions

Année:

2013

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2013

Mechanistic and Energetic Aspects of the Thermal and Photochemical Redox Chemistry of the Octanuclear Cubane Complexes, Fe III8 (μ 4 -O 4 )(μ-pyrazolate) 12 X 4 (X = Cl or Br)

Ferraudi, Guillermo, Piñero, Dalice, Chakraborty, Indranil, Raptis, Raphael G., Lappin, A. Graham, Berlin, Nicholas

Journal:

Journal of Physical Chemistry A

Année:

2010

Langue:

english

Fichier:

PDF, 935 KB

english, 2010

The use of isotopes in the determination of absolute bioavailability of drugs in humans

Lappin, Graham, Rowland, Malcolm, Garner, R Colin

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2006

Langue:

english

Fichier:

PDF, 143 KB

english, 2006

P-911 Preoperative serum erythropoietin concentration as an outcomepredictor in patients following surgery for non small cell lung cancer

Paul, I., Lappin, T., Graham, A.

Journal:

Lung Cancer

Année:

2005

Langue:

english

Fichier:

PDF, 245 KB

english, 2005

Unfolding of the [Cu 2 (1,3-bis(9-methyl-1,10-phenanthrolin-2-yl)propane) 2 ] 2+ Helicate. Coupling of the Chlorocarbon Dehalogenation to the Unfolding Process

Lemus, L., Guerrero, J., Costamagna, J., Estiu, G., Ferraudi, G., Lappin, A. Graham, Oliver, A., Noll, B. C.

Journal:

Inorganic Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 2.38 MB

english, 2010

Redox chemistry of bis(2,9-dimethyl-4,7-bis(sulfonatophenyl)-1,10-phenanthrolinato)copper(II/I). Reactions with nickel oxime imine complexes

Allan, Anne E., Lappin, A. Graham, Laranjeira, Mauro C. M.

Journal:

Inorganic Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 674 KB

english, 1984

Inner-sphere electron-transfer stereoselectivities in the oxidation of bis(1,2-diaminoethane)cobalt(II) derivatives by tris(oxalato)cobaltate(3-)

Marusak, Rosemary A., Ivanca, Marie A., Haller, Kenneth J., Lappin, A. Graham.

Journal:

Inorganic Chemistry

Année:

1991

Langue:

english

Fichier:

PDF, 790 KB

english, 1991

Direct determination of the self-exchange rate of a nickel(IV/III) bis(oxime-imine) complex. Investigation of orientation effects in electron-transfer reactions

Marusak, Rosemary A., Sharp, Christopher, Lappin, A. Graham

Journal:

Inorganic Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 1.72 MB

english, 1990

Electron-transfer reactions of bis(dipeptide)nickel(III) complexes

Schadler, Steven E., Sharp, Christopher, Lappin, A. Graham

Journal:

Inorganic Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 2.39 MB

english, 1992

X-ray and molecular structure of the diastereomeric pair .LAMBDA.- and .DELTA.-tris(ethylenediamine)cobalt(III) .DELTA.-(ethylenediamine)bis(oxalato)cobaltate(II) dioidide trihydrate and monohydrate and comparisons with [.LAMBDA.-Co(en)3][.DELTA.-Co(gly)(ox)2]I.cntdot.H2O

Lappin, A. Graham, Haller, Kenneth J., Warren, Robert M. L., Tatehata, Akira

Journal:

Inorganic Chemistry

Année:

1993

Langue:

english

Fichier:

PDF, 841 KB

english, 1993

Stereoselectivity as a probe of reaction mechanism in the oxidation of tris(ethylenediamine)cobalt(2+) and its derivatives by ethylenediaminetetraacetatocobaltate(1-)

Osvath, Peter, Lappin, A. Graham

Journal:

Inorganic Chemistry

Année:

1987

Langue:

english

Fichier:

PDF, 2.14 MB

english, 1987

Stereoselectivity in the reduction of tris(oxalato)cobaltate(3-) by tris(ethylenediamine)cobalt(2+) and its derivatives

Marusak, Rosemary A., Osvath, Peter, Kemper, Margaret, Lappin, A. Graham

Journal:

Inorganic Chemistry

Année:

1989

Langue:

english

Fichier:

PDF, 1.66 MB

english, 1989